203303

Bisindolylmaleimide V

A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM).

• Synonym(s): Bisindolylmaleimide V, 2,3- bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045, 2,3-bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045
• Empirical Formula (Hill Notation): C₂₁H₁₅N₃O₂
• CAS Number: 113963-68-1
• Molecular Weight: 341.36
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: red-orange
• solubility: DMSO: 10 mg/mL; methanol: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C21H15N3O2/c1-24-20(25)18(14-10-22-16-8-4-2-6-12(14)16)19(21(24)26)15-11-23-17-9-5-3-7-13(15)17/h2-11,22-23H,1H3
• InChI key: SWAWYMIKGOHZMR-UHFFFAOYSA-N

Description

General description

A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM). Blocks the activation of mitogen-stimulated protein kinase p70^s6k/p85^s6kin vivo (IC₅₀ 8 µM).

A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM). Blocks the activation of p70^s6k/p85^s6kin vivo (IC₅₀ = 8 µM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Negative control compound for protein kinase C inhibition

Product does not compete with ATP.

Reversible: no

Target IC₅₀: >100 µM as negative control compound for protein kinase C inhibition; 8 µM in blocking the activation of mitogen-stimulated protein kinase p70s6k/p85s6k in vivo

Warning

Toxicity: Standard Handling (A)

Other Notes

Marmy-Conus, N., et al. 2002. FEBS Lett. 26094 (In Press) 1-6.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem.266, 15771.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable