N-terminal GST-tagged fusion protein corresponding to residues 505-793 of human PTP alpha (complete D2 catalytic domain).
Application
Anti-PTPα Antibody detects level of PTPα & has been published & validated for use in WB.
Research Category Signaling
Research Sub Category Kinases & Phosphatases
Quality
Routinely evaluated by immunoblot in in NIH 3T3 cell lysates.
Target description
130kDa
Physical form
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
ImmunoAffinity Purified
Storage and Stability
1 year at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
Certificates of Analysis (COA)
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The Journal of biological chemistry, 277(24), 21922-21929 (2002-03-30)
During mitosis, the catalytic activity of protein-tyrosine phosphatase (PTP) alpha is enhanced, and its inhibitory binding to Grb2, which specifically blocks Src dephosphorylation, is decreased. These effects act synergistically to activate Src in mitosis. We show here that these effects
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