05-1946

Anti-USP7 Antibody, clone 1G7

clone 1G7, from mouse

• Synonym(s): ubiquitin specific peptidase 7 (herpes virus-associated), Ubiquitin-specific-processing protease 7, ubiquitin specific protease 7 (herpes virus-associated), Herpesvirus-associated ubiquitin-specific protease, Herpes virus-associated ubiquitin-specific pr
• UNSPSC Code: 12352203
• eCl@ss: 32160702

Properties

• biological source: mouse
• Quality Level: 100
• antibody product type: primary antibodies
• clone: 1G7, monoclonal
• species reactivity: human
• species reactivity (predicted by homology): mouse (based on 100% sequence homology)
• technique(s): immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• isotype: IgG1κ
• NCBI accession no.: NP_003461.2
• UniProt accession no.: Q93009
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... USP7(7874)

Description

General description

Ubiquitin carboxyl-terminal hydrolase 7 (USP7) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates.[Saridakis, 2005] Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, Ubiquitin carboxyl-terminal hydrolase 7 activity generally stabilizes its substrate proteins. Ubiquitin carboxyl-terminal hydrolase 7 is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.[Canning, 2004]

Specificity

This antibody recognizes USP7.

Immunogen

Histadine-tagged recombinant protein corresponding to human USP7.

Application

This Anti-USP7 Antibody, clone 1G7 is validated for use in WB, IP, IH for the detection of USP7.

Quality

Evaluated by Western Blot in HeLa lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected USP7 on 10 µg of HeLa cell lysate.

Target description

~ 128kDa Observed

Physical form

Format: Purified

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable