Biochemical and biophysical research communications, 284(1), 50-56 (2001-05-26)
Rab proteins intervene in the controlled exocytosis of catecholamines by chromaffin cells from the adrenal medulla. These proteins are posttranslationally modified by digeranylgeranylation and carboxymethylation. Reversible carboxymethylation terminating the isoprenylation pathway may play an important role in both the functioning
Journal of medicinal chemistry, 45(2), 504-510 (2002-01-11)
A series of tight binding carbonic anhydrase (CA) activators was obtained by reaction of amino-azoles (3-amino-pyrazole, 2-amino-imidazole, and 5-amino-tetrazole) with tri- or tetrasubstituted pyrylium salts. Many of the new pyridinium salts incorporating azole moieties reported here proved to be efficient
Journal of the American Chemical Society, 124(30), 8766-8767 (2002-07-26)
This communication is concerned with deviations from linearity in Brønsted-type nucleophilicity plots as indicators of changes in transition-state structures, in particular as related to solvational effects. Increasing dimethyl sulfoxide (DMSO) content of DMSO-water mixtures removes the leveling off observed in
Drug metabolism and disposition: the biological fate of chemicals, 30(5), 541-547 (2002-04-16)
Carboxylesterases hydrolyze numerous endogenous and foreign compounds with diverse structures. Humans and rodents express multiple forms of carboxylesterases, which share a high degree of sequence identity (approximately 70%). Alignment analyses locate in carboxylesterases several functional subsites such the catalytic triad
Journal of molecular biology, 330(3), 593-606 (2003-07-05)
Esterases and deacetylases active on carbohydrate ligands have been classified into 14 families based upon amino acid sequence similarities. Enzymes from carbohydrate esterase family seven (CE-7) are unusual in that they display activity towards both acetylated xylooligosaccharides and the antibiotic
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