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JKA5101

Sigma-Aldrich

HS-PEG7500-COOH

average MN 7,500, COOH, cross-linking reagent polymerization reactions thiol reactive, cross-linking reagent polymerization reactions amine reactive

Synonym(s):

HS-PEG-COOH, Polyethylene glycol, Thiol-PEG-Carboxyl, HS-PEG-COOH

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About This Item

Linear Formula:
HS(CH2CH2O)nCH2COOH
UNSPSC Code:
12162002
NACRES:
NA.23

product name

HS-PEG7500-COOH, average Mn 7,500

form

solid

mol wt

average Mn 7,500

reaction suitability

reagent type: cross-linking reagent
reaction type: Polymerization Reactions
reactivity: amine reactive
reagent type: cross-linking reagent
reaction type: Polymerization Reactions
reactivity: thiol reactive

polymer architecture

shape: linear
functionality: heterobifunctional

General description

Product is a thiolated carboxylic-polyethylene . 4α;-sulfanyl—ω carboxy PEG (HS–PEG–COOH) heterobifunctional PEGs with functional end-groups of very different reactivity. HS-PEG-COOH inhibits nonspecific binding to living cells.

Application

HS-PEG-COOH may be tethered to the gold nanoparticle end during the fabrication of epidermal growth factor (EGF)-conjugated surface-enhanced Raman spectroscopy (SERS) nanoparticles. HS-PEG-COOH was coated onto silicon-on-insulator photonic biosensor chips. Quantum dots (QD)/ virus-like particles (VLPs) could be obtained only from HS-PEG-COOH-coated QDs. It may be used to stabilize nanoparticles and prevent its aggregation.
Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization

Legal Information

Product of JenKem Technology

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Antibody-functionalized SERS tags with improved sensitivity.
Guarrotxena N and Bazan GC
Chemical Communications (Cambridge, England), 47(31), 8784-8786 (2011)
SOI optical microring resonator with poly (ethylene glycol) polymer brush for label-free biosensor applications
De Vos, K, et al.
Biosensors And Bioelectronics, 24(8), 2528-2533 (2009)
Quantum dot encapsulation in viral capsids."
Dixit SK, et al.
Nano Letters, 6(9), 1993-1999 (2006)
Detection of circulating tumor cells in human peripheral blood using surface-enhanced Raman scattering nanoparticles.
Wang X, et al.
Cancer Research, 71(5), 1526-1532 (2011)
Nam, K., et al.
Biomaterials, 33(32) (2012)
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