A75900
1-Aminopiperidine
97%
Synonym(s):
Pentamethylenehydrazine, Piperidin-1-ylamine
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About This Item
Empirical Formula (Hill Notation):
C5H12N2
CAS Number:
Molecular Weight:
100.16
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
assay
97%
form
liquid
refractive index
n20/D 1.475 (lit.)
bp
146 °C/730 mmHg (lit.)
density
0.928 g/mL at 25 °C (lit.)
SMILES string
NN1CCCCC1
InChI
1S/C5H12N2/c6-7-4-2-1-3-5-7/h1-6H2
InChI key
LWMPFIOTEAXAGV-UHFFFAOYSA-N
Application
1-Aminopiperidine can be used as a reactant to prepare N-1-piperidinylformamide by reacting with ethyl formate. It is also reacted with aluminum hydride and gallium hydride to form corresponding hydrazides. In the pharmaceutical industry, aminopiperidine is utilized as a building block to synthesize various bioactive molecules.
Reactant for synthesis of:
- CB1 cannabinoid receptor ligands†
- Hydrazones†
- Tetrahydronaphthalene derivatives affecting proliferation and nitric oxide production in LPS activated RAW 264.7 macrophages
- Phosphorus(V) hydrazines
Other Notes
remainder piperidine
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
3 - Flammable liquids
wgk_germany
WGK 3
flash_point_f
96.8 °F - closed cup
flash_point_c
36 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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In a search for novel DPP-IV inhibitors, 2-aminobenzo[a]quinolizines were identified as submicromolar HTS hits. Due to the difficult synthetic access to this compound class, 1,3-disubstituted 4-aminopiperidines were used as model compounds for optimization. The developed synthetic methodology and the SAR
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