901743
Poly(OEGMA)
aldehyde functionalized, 25 wt% solution in water
Synonym(s):
PEGMA, POEGMA
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About This Item
Linear Formula:
[CH2CCH3(COO(CH2CH2O)8CH3)]m[CH2CCH3(CONHCH2COH)]q
UNSPSC Code:
12162002
NACRES:
NA.23
Recommended Products
form
solution
mol wt
~20,000 g/mol
color
clear colorless to pale yellow
storage temp.
2-8°C
General description
Poly(oligoethylene glycol methacrylate) (POEGMA), is a comb-shaped, graft copolymer consisting of hydrophilic oligomer PEG chains grafted to a hydrophobic polymethacrylate backbone. POEGMA has been suggested as a viable alternative to poly(ethylene glycol) (PEG) in biological and biomaterial applications. POEGMA has been reported to improve pharmacokinetic properties of protein and peptide conjugates[1][2], enhance the stability and gene silencing efficiency of siRNAs[3], as an anti-fouling surface for biosensors[4], and eliminate PEG antigenicity[5][6]. In addition to use in biomolecule-polymer conjugates, PEOGMA has also seen wide spread use in tissue engineering applications, such as hydrogel synthesis. Aldehyde-functionalized POEGMA can be readily used with the corresponding hydrazide-functionalized POEGMA for rapid gelation via reversible hydrazone bond formation[7]. Due to the reversibility of the bond formation and the low viscosity of the precursors, resulting hydrogels can be used as injectable tissue engineering matrices, local drug delivery vehicles for small molecules, or as joint lubricants[8][9]. In addition, the physical properties of the resulting hydrogels, such as LCST, gelation rates, swelling kinetics, degredation kinetics, and mechanical properties, can all be readily controlled by solution concentration and the ratios of each solution[10][11].
Preparation Note
This product is provided as a 25 wt% solution in water, ready to be diluted for your specific application. Please see the technical bulletin on the product page for dilution and hydrogel preparation instructions.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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A. brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity.
Qi Y, et al.
Nmr in Biomedicine, 1, 0002-0002 (2016)
?Off-the-shelf? thermoresponsive hydrogel design: tuning hydrogel properties by mixing precursor polymers with different lower-critical solution temperatures.
Bakaic E, et al.
Royal Society of Chemistry Advances, 5, 33364-33376 (2015)
A brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity.
Qi Y, et al.
Nature Biomedical Engineering, 1, 2-2 (2016)
Injectable hydrogels based on poly(ethylene glycol) and derivatives as functional biomaterials.
Bakaic E, et al.
Royal Society of Chemistry Advances, 5, 35469-35486 (2015)
?Off-the-shelf? thermoresponsive hydrogel design: tuning hydrogel properties by mixing precursor polymers with different lower-critical solution temperatures.
Bakaic E, et al.
Royal Society of Chemistry Advances, 5, 33364-33376 (2015)
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