697095

2-Chloropyridine-3-boronic acid

• Synonym(s): (2-Chloro-3-pyridyl)boronic acid, (2-Chloropyridin-3-yl)boronic acid, Dihydroxy(2-chloro-3-pyridyl)borane
• Empirical Formula (Hill Notation): C₅H₅BClNO₂
• CAS Number: 381248-04-0
• Molecular Weight: 157.36
• MDL number: MFCD03094997
• UNSPSC Code: 12352103
• PubChem Substance ID: 329761887
• NACRES: NA.22

Properties

• form: powder
• mp: 121-134 °C
• storage temp.: 2-8°C
• SMILES string: OB(O)c1cccnc1Cl
• InChI: 1S/C5H5BClNO2/c7-5-4(6(9)10)2-1-3-8-5/h1-3,9-10H
• InChI key: VRDAOVQZVXYRNH-UHFFFAOYSA-N

Description

Application

Reactant for:

• Synthesis of Et canthinone-3-carboxylates from Et 4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylate via a Pd-catalyzed Suzuki-Miyaura coupling and a Cu-catalyzed amidation reaction
• Preparation of arylmethylpyrrolidinylmethanols and amine derivatives via reaction with MIDA followed by Suzuki reaction with halides or amination with amines
• Preparation of arylazabicyclooctane derivatives as potential arginine vasopressin receptor antagonists
• Regioselective preparation of halo-oligopyridines and oligopyridines by the Suzuki-Miyaura cross-coupling reaction

May contain varying amounts of anhydride

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves