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540935

Sigma-Aldrich

4-(N-Boc-amino)piperidine

96%

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About This Item

Empirical Formula (Hill Notation):
C10H20N2O2
CAS Number:
73874-95-0
Molecular Weight:
200.28
MDL number:
MFCD00798171
UNSPSC Code:
12352100
PubChem Substance ID:
24878503
NACRES:
NA.22

assay

96%

mp

162-166 °C (lit.)

SMILES string

CC(C)(C)OC(=O)NC1CCNCC1

InChI

1S/C10H20N2O2/c1-10(2,3)14-9(13)12-8-4-6-11-7-5-8/h8,11H,4-7H2,1-3H3,(H,12,13)

InChI key

CKXZPVPIDOJLLM-UHFFFAOYSA-N

General description

4-(N-Boc-amino)piperidone is a piperidone derivative.

Application

4-(N-Boc-amino)piperidone may be used as a functionalization reagent for introduction of a primary and a tertiary amino group to poly(2-isopropyl-2-oxazoline.
Pharma building block.
Used in a synthesis of a piperidine-4-carboxamide CCR5 antagonist with potent anti-HIV-1 activity.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Poly (2-isopropyl-2-oxazoline)-poly (L-glutamate) block copolymers through ammonium-mediated NCA polymerization.
Meyer M and Schlaad H.
Macromolecules, 39(11), 3967-3970 (2006)
Apos Dermatakis et al.
Bioorganic & medicinal chemistry, 11(8), 1873-1881 (2003-03-28)
A series of oxindole CDK2 inhibitors was synthesized. These novel analogues have a saturated monosubstituted cyclic moiety at their C-4 position that mimics the ribofuranoside of ATP. This substitution afforded agents with increased potency relative to the parent indolinone and
Shinichi Imamura et al.
Journal of medicinal chemistry, 49(9), 2784-2793 (2006-04-28)
We incorporated various polar groups into previously described piperidine-4-carboxamide CCR5 antagonists to improve their metabolic stability in human hepatic microsomes. Introducing a carbamoyl group into the phenyl ring of the 4-benzylpiperidine moiety afforded the less lipophilic compound 5f, which possessed

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