470791

2,6-Difluorophenylboronic acid

98%

• Linear Formula: F₂C₆H₃B(OH)₂
• CAS Number: 162101-25-9
• Molecular Weight: 157.91
• MDL number: MFCD00792436
• UNSPSC Code: 12352103
• PubChem Substance ID: 24870682
• NACRES: NA.22

Properties

• assay: 98%
• mp: 147-149 °C (lit.)
• functional group: fluoro
• SMILES string: OB(O)c1c(F)cccc1F
• InChI: 1S/C6H5BF2O2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3,10-11H
• InChI key: DBZAICSEFBVFHL-UHFFFAOYSA-N

Description

Application

2,6-Difluorophenylboronic acid can be used:

• As a substrate in the model reaction of Suzuki–Miyaura coupling with 4-chloro-3-methylanisole.
• To prepare 4-bromo-2,3′,5′,6-tetrafluorobiphenyl, a key intermediate for the synthesis of 2,6-difluorinated oligophenyls applicable in organic semiconductors.
• To prepare ethyl 4-(2,6-difluorophenyl)nicotinate, a key intermediate for the synthesis of 4-phenyl pyridine based potent TGR5 agonists.

Other Notes

Contains varying amounts of the anhydride

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves