441562

trans-1-Acetyl-4-hydroxy-L-proline

≥98%, for peptide synthesis

• Synonym(s): N-Acetyl-L-hydroxyproline
• Empirical Formula (Hill Notation): C₇H₁₁NO₄
• CAS Number: 33996-33-7
• Molecular Weight: 173.17
• Beilstein/REAXYS Number: 84043
• EC Number: 251-780-6
• MDL number: MFCD00037339
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24867668
• NACRES: NA.22

Properties

• product name: trans-1-Acetyl-4-hydroxy-L-proline, ≥98%
• assay: ≥98%
• form: powder
• optical activity: [α]20/D −119°, c = 4 in H₂O
• reaction suitability: reaction type: solution phase peptide synthesis
• mp: 132-133 °C (dec.) (lit.)
• application(s): peptide synthesis
• SMILES string: CC(=O)N1C[C@H](O)C[C@H]1C(O)=O
• InChI: 1S/C7H11NO4/c1-4(9)8-3-5(10)2-6(8)7(11)12/h5-6,10H,2-3H2,1H3,(H,11,12)/t5-,6+/m1/s1
• InChI key: BAPRUDZDYCKSOQ-RITPCOANSA-N

Description

Application

trans-1-Acetyl-4-hydroxy-L-proline can be used:

• In the stereospecific synthesis of 4-fluoroglutamic acid.
• To synthesize molecular targets for von Hippel-Lindau (VHL) E3 ubiquitin ligase.
• As a precursor to synthesize pseudopoly(amino acids) such as poly(trans-4-hydroxy-4-acyl-L-proline ester) and a biodegradable polymer, poly(lactic acid-glycolic acid-4-hydroxyproline).

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H318
• pcodes: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves