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435201

Sigma-Aldrich

Hydroxypropyl methyl cellulose phthalate

extent of labeling: 31 wt. % phthalyl

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About This Item

CAS Number:
9050-31-1
MDL number:
MFCD00147216
UNSPSC Code:
12162002

extent of labeling

7 wt. % hydroxypropoxy
20 wt. % methoxy
31 wt. % phthalyl

mp

>145 °C (dec.) (lit.)

solubility

H2O: soluble (Limited solubility at low pH, soluble at pH ≥4.2.)

density

0.6 g/mL at 25 °C (lit.)

InChI

1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)

InChI key

DOUYETYNHWVLEO-UHFFFAOYSA-N

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Application

Coatings become soluble in mild aqueous acid and readily dissolve in aqueous base.
Films can be applied from water or organic solvent.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
10421JS
11422PG
01430TR

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Zhi Min Wu et al.
International journal of pharmaceutics, 425(1-2), 1-8 (2012-01-18)
In this work, we designed and developed a two-stage delivery system composed of enteric capsule and cationic nanoparticles for oral delivery of insulin. The enteric capsule was coated with pH-sensitive hydroxypropyl methylcellulose phthalate (HP55), which could selectively release insulin from
T Comoglu et al.
Drug delivery, 15(5), 295-302 (2008-09-03)
Pantoprazole is a proton pump inhibitor prodrug used in the treatment of gastric ulcers and gastroesophageal disease. Pantoprazole must be absorbed in the gastrointestinal tract and because it is unstable under acidic conditions, enteric delivery systems are required. The purpose
Manu Sharma et al.
International journal of nanomedicine, 6, 2097-2111 (2011-11-25)
Particulate systems have received increasing attention for oral delivery of biomolecules. The objective of the present study was to prepare submicron particulate formulations of papain for pH-dependent site-specific release using pH-sensitive polymers. Enteric submicron particle formulations of papain were prepared
Min-Soo Kim et al.
Archives of pharmacal research, 30(8), 1008-1013 (2007-09-21)
The objective of this study was to investigate the influence of various water-soluble additives and HPMCP as an enteric polymer into Surelease for the developement of oral controlled release system containg tamsulosin hydrochloride. The drug loaded pellets were coated with
Hasan Rafati et al.
Journal of pharmaceutical sciences, 98(7), 2401-2411 (2009-02-20)
In this study, pH responsive macroparticles incorporating peppermint oil (PO) were prepared using a simple emulsification/polymer precipitation technique. The formulations were examined for their properties and the desired quality was then achieved using a quality by design (QBD) approach. For
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