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357847

Sigma-Aldrich

2-Chloro-6-methylpyridine-3-carboxylic acid

97%

Synonym(s):

2-Chloro-6-methyl-3-pyridinecarboxylic acid, 2-Chloro-6-methylnicotinic acid

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About This Item

Empirical Formula (Hill Notation):
C7H6ClNO2
CAS Number:
Molecular Weight:
171.58
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

assay

97%

mp

162-164 °C (lit.)

SMILES string

Cc1ccc(C(O)=O)c(Cl)n1

InChI

1S/C7H6ClNO2/c1-4-2-3-5(7(10)11)6(8)9-4/h2-3H,1H3,(H,10,11)

InChI key

ACQXHCHKMFYDPM-UHFFFAOYSA-N

General description

2-Chloro-6-methylpyridine-3-carboxylic acid (2-Chloro-6-methylnicotinic acid) is a nicotinic acid derivative.

Application

2-Chloro-6-methylpyridine-3-carboxylic acid (2-Chloro-6-methylnicotinic acid) may be used in the synthesis of 6-methyl-2-thiophenoxynicotinic acid, required for the preparation of europium complex for staining the nucleolus of NIH 3T3, HeLa and HDF cells.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


Certificates of Analysis (COA)

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Nicotinic acid derivatives. VI. Some transformations of 2-chloro-6-methylnicotinic acid.
P Nantka-Namirski et al.
Polish journal of pharmacology and pharmacy, 26(5), 545-548 (1974-07-01)
Junhua Yu et al.
Journal of the American Chemical Society, 128(7), 2294-2299 (2006-02-16)
A europium complex selectively staining the nucleolus of NIH 3T3, HeLa, and HDF cells is reported. This complex possesses not only the advantage of the long lifetime of europium emission (0.3 ms), but also a chromophore that allows excitation at

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