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341576

Sigma-Aldrich

(3aR,4S,5R,6aS)-(−)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one

98%

Synonym(s):

(−)-Corey lactone

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1 G
$134.00

About This Item

Empirical Formula (Hill Notation):
C8H12O4
CAS Number:
Molecular Weight:
172.18
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22

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Quality Level

assay

98%

form

solid

optical activity

[α]20/D −44°, c = 1.4 in methanol

mp

117-119 °C (lit.)

functional group

ester
hydroxyl

SMILES string

OC[C@H]1[C@H](O)C[C@@H]2OC(=O)C[C@H]12

InChI

1S/C8H12O4/c9-3-5-4-1-8(11)12-7(4)2-6(5)10/h4-7,9-10H,1-3H2/t4-,5-,6-,7+/m1/s1

InChI key

VYTZWRCSPHQSFX-GBNDHIKLSA-N

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Darya Zibrova et al.
The Biochemical journal, 474(6), 983-1001 (2016-12-23)
Activation of AMP-activated protein kinase (AMPK) in endothelial cells regulates energy homeostasis, stress protection and angiogenesis, but the underlying mechanisms are incompletely understood. Using a label-free phosphoproteomic analysis, we identified glutamine:fructose-6-phosphate amidotransferase 1 (GFAT1) as an AMPK substrate. GFAT1 is
Erin M Anderson et al.
Tissue engineering. Part A, 21(7-8), 1217-1227 (2014-12-02)
Biomaterials may improve outcomes of endothelial progenitor-based therapies for the treatment of ischemic cardiovascular disease, due to their ability to direct cell behavior. We hypothesized that local, sustained delivery of exogenous vascular endothelial growth factor (VEGF) and stromal cell-derived factor
Emilie Montenont et al.
Blood advances, 5(9), 2362-2374 (2021-05-05)
Human anucleate platelets cannot be directly modified using traditional genetic approaches. Instead, studies of platelet gene function depend on alternative models. Megakaryocytes (the nucleated precursor to platelets) are the nearest cell to platelets in origin, structure, and function. However, achieving
Jiwon Song et al.
Biofabrication, 9(1), 015002-015002 (2016-12-03)
Transplantation of human pluripotent stem cells (hPSC) differentiated into insulin-producing β cells is a regenerative medicine approach being investigated for diabetes cell replacement therapy. This report presents a multifaceted transplantation strategy that combines differentiation into stem cell-derived β (SC-β) cells
Aaron J Rogers et al.
IEEE transactions on bio-medical engineering, 66(12), 3436-3443 (2019-03-21)
Cardiovascular research and regenerative strategies have been significantly limited by the lack of relevant cell culture models that can recreate complex hemodynamic stresses associated with pressure-volume changes in the heart. To address this issue, we designed a biomimetic cardiac tissue

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