338419

(R)-(+)-3-Chloro-1-phenyl-1-propanol

98%

• Synonym(s): α-(2-Chloroethyl)benzyl alcohol, (R)-(+)-α-(2-Chloroethyl)benzyl alcohol, (R)-(+)-3-Chloro-1-phenylpropanol
• Linear Formula: ClCH₂CH₂CH(C₆H₅)OH
• CAS Number: 100306-33-0
• Molecular Weight: 170.64
• Beilstein/REAXYS Number: 5250766
• MDL number: MFCD00075128
• UNSPSC Code: 12352101
• PubChem Substance ID: 24860543
• NACRES: NA.22

Properties

• assay: 98%
• form: solid
• optical activity: [α]24/D +26°, c = 1 in chloroform
• optical purity: ee: 99% (GLC)
• mp: 58-60 °C (lit.)
• SMILES string: O[C@H](CCCl)c1ccccc1
• InChI: 1S/C9H11ClO/c10-7-6-9(11)8-4-2-1-3-5-8/h1-5,9,11H,6-7H2/t9-/m1/s1
• InChI key: JZFUHAGLMZWKTF-SECBINFHSA-N

Description

Application

(R)-(+)-3-Chloro-1-phenyl-1-propanol may be used as a building block in the synthesis of antidepressants such as (R)- and (S)-tomoxetine, fluoxetine and nisoxetine. It may also be used in the synthesis of biologically active 2-substituted chromans such as tephrowatsin E.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves