324124

2-Chloro-1,3,2-benzodioxaphosphorin-4-one

95%

• Synonym(s): SalPCl, Salicyl chlorophosphite
• Empirical Formula (Hill Notation): C₇H₄ClO₃P
• CAS Number: 5381-99-7
• Molecular Weight: 202.53
• Beilstein/REAXYS Number: 1311951
• MDL number: MFCD00013353
• UNSPSC Code: 12352005
• PubChem Substance ID: 24859425
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: 95%
• form: solid
• reaction suitability: reaction type: Buchwald-Hartwig Cross Coupling Reaction; reaction type: Heck Reaction; reaction type: Hiyama Coupling; reaction type: Negishi Coupling; reaction type: Sonogashira Coupling; reaction type: Stille Coupling; reaction type: Suzuki-Miyaura Coupling; reagent type: ligand
• bp: 127-128 °C/11 mmHg (lit.)
• mp: 36-40 °C (lit.)
• functional group: phosphine
• storage temp.: 2-8°C
• SMILES string: ClP1OC(=O)c2ccccc2O1
• InChI: 1S/C7H4ClO3P/c8-12-10-6-4-2-1-3-5(6)7(9)11-12/h1-4H
• InChI key: BVOITXUNGDUXRW-UHFFFAOYSA-N

Description

Application

2-Chloro-1,3,2-benzodioxaphosphorin-4-one is used as a reagent:

• In the phosphorylation and phosphitylation of alcohols.
• In the formation of H-phosphonates which are commonly utilized in the synthesis of nucleotides.
• To synthesize nucleoside triphosphates by treating with acyl protected nucleoside.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• supp_hazards: EUH014
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 235.4 °F - closed cup
• flash_point_c: 113 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges