TPA-induced inhibition of gap junctional intercellular communication is not mediated through free radicals.: This research explores the role of N,N′-Diphenyl-p-phenylenediamine (DPPD) in cellular communication, providing insights into its applications in high-performance rubber stabilizers and life science manufacturing chemicals. (Hasler et al., 1990).
The journal of physical chemistry. A, 113(16), 4780-4787 (2008-11-28)
Coarse-grained (CG) molecular dynamics (MD) simulations are performed to study the insertion of cyclic peptide nanotubes into cell membranes and to examine whether cyclic peptide nanotubes can function as an ion channel and thereby as an antibacterial agent. To do
Molecular and biochemical parasitology, 118(1), 33-40 (2001-11-13)
It has been known for almost a century that normal human serum can lyse the extracellular blood parasite Trypanosoma brucei brucei. This process is a result of a non-immune killing factor in human sera known as trypanosome lytic factor (TLF).
Salicylic acid is a widely used nonsteroidal anti-inflammatory drug (NSAID). But it is known to cause serious liver damage occasionally. Mitochondrial dysfunction and oxidative stress are predicted to be the major factors of salicylic acid-induced liver injury. We investigated the
Evidence that membrane-associated amyloid aggregate growth can impart membrane damage represents one possible mechanism for the neurodegeneration associated with deposited amyloid-beta protein (Abeta) aggregates in the brains of Alzheimer's disease (AD) patients. This potential pathogenic event necessitates an understanding of
Toxicology in vitro : an international journal published in association with BIBRA, 16(2), 151-158 (2002-03-01)
Ethacrynic acid, a loop diuretic drug, caused lipid peroxidation in isolated rat hepatocytes. The thiobarbituric acid reactive substances (TBARS) formation showed a good correlation with the leakage of glutamic-oxaloacetic acid transaminase (GOT) from the hepatocytes. The addition of antioxidants such
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