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17343

Sigma-Aldrich

Bromhexine hydrochloride

≥98.0% (AT)

Synonym(s):

2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine hydrochloride, N-(2-Amino-3,5-dibromobenzyl)-N-methylcyclohexylamine hydrochloride, Bromohexine hydrochloride

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25 G
$93.30

About This Item

Empirical Formula (Hill Notation):
C14H20Br2N2 · HCl
CAS Number:
Molecular Weight:
412.59
Beilstein/REAXYS Number:
4848376
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
form:
powder
assay:
≥98.0% (AT)

$93.30


In StockDetails


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Quality Level

assay

≥98.0% (AT)

form

powder

functional group

amine
bromo

SMILES string

Cl.CN(Cc1cc(Br)cc(Br)c1N)C2CCCCC2

InChI

1S/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H

InChI key

UCDKONUHZNTQPY-UHFFFAOYSA-N

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General description

Bromhexine hydrochloride is a bronchial mucolytic[1].

Application

Bromhexine hydrochloride was used in the secretion of pancreatic juice of low viscosity[1].

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Tatsuhiro Tsujimoto et al.
Alcoholism, clinical and experimental research, 29(12 Suppl), 272S-276S (2005-12-31)
Abstinence is a prerequisite for the treatment of alcoholic chronic pancreatitis, but there are patients who have repeated attacks because of their inability to abstain and the consequent congestive effects of the continued alcohol intake on pancreatic juice. Bromhexine hydrochloride
Amit Kumar Aggarwal et al.
Drug development and industrial pharmacy, 38(11), 1319-1327 (2012-01-31)
The aim of the present study was to prepare the amino acid prodrugs of bromhexine hydrochloride to improve its solubility. All the prodrugs were synthesized by first reacting bromhexine with tert-butoxycarbonyl (Boc) protected amino acid and then deprotection was carried
J L Vercher-Conejero et al.
Revista espanola de medicina nuclear, 30(2), 97-100 (2010-06-24)
Splenosis is defined as the heterotopic autotransplantation of splenic tissue because of a ruptured spleen due to trauma or surgery. It is a benign and incidental finding, although imaging tests may sometimes orient toward malignancy simulating renal tumors, abdominal lymphomas
Ibrahim El Hachmi et al.
Acta orthopaedica Belgica, 78(5), 694-696 (2012-11-21)
Glomus tumours are benign lesions occurring essentially in the hand, with a predilection for the subungueal area. Even though they have been reported in literature, extradigital localisations of glomus tumours are frequently misdiagnosed; they never lead to bone osteolysis. We
Shigeki Asada et al.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 20(3), 571-578 (2011-07-21)
The purpose of this study was to clarify the causes of the increase in the posterior tibial slope during open-wedge high tibial osteotomy (HTO) and to investigate whether its changes influenced the correction angle in frontal plane. We retrospectively reviewed

Questions

  1. What solvent should be used and what stock concentration is recommended?

    1 answer
    1. The solubility of this product has not been determined. However, various sources report that this material is soluble in water at 3.33 mg/mL, in DMSO at 8 – 20 mg/mL, and in ethanol at 2.44 mg/L. Warming and sonication may be required. Stock solutions are reported to be stable at -80°C for 6 months and -20°C for 1 month. This information has not been validated.

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