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163341

Sigma-Aldrich

2-Nitrophenylacetonitrile

98%

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About This Item

Linear Formula:
O2NC6H4CH2CN
CAS Number:
610-66-2
Molecular Weight:
162.15
EC Number:
210-231-0
MDL number:
MFCD00007183
UNSPSC Code:
12352100
PubChem Substance ID:
24849743
NACRES:
NA.22

assay

98%

form

powder

mp

82-85 °C (lit.)

SMILES string

[O-][N+](=O)c1ccccc1CC#N

InChI

1S/C8H6N2O2/c9-6-5-7-3-1-2-4-8(7)10(11)12/h1-4H,5H2

InChI key

YPRFCQAWSNWRLM-UHFFFAOYSA-N

Application

2-Nitrophenylacetonitrile was used in synthesis of 2 or 2,4-substituted α-carbolines via a one-pot tandem reaction of α,β-unsaturated ketones. It was used in the synthesis of strychnine.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Xiaofei Zhang et al.
Organic & biomolecular chemistry, 12(2), 355-361 (2013-11-23)
An effective and convenient method has been developed for the preparation of 2 or 2,4-substituted α-carbolines via a one-pot tandem reaction of α,β-unsaturated ketones with 2-nitrophenylacetonitrile in the presence of zinc dust, acetic acid and triethylamine. This protocol presents a
Takashi Ohshima et al.
Journal of the American Chemical Society, 124(49), 14546-14547 (2002-12-06)
The enantioselective total synthesis of (-)-strychnine was accomplished through the use of the highly practical catalytic asymmetric Michael reaction (0.1 mol % of (R)-ALB, more than kilogram scale, without chromatography, 91% yield and >99% ee) as well as a tandem

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