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Sigma-Aldrich

Tributyl phosphate

97%

Synonym(s):

TBP, TBPA

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About This Item

Linear Formula:
(CH3(CH2)3O)3PO
CAS Number:
126-73-8
Molecular Weight:
266.31
Beilstein/REAXYS Number:
1710584
EC Number:
204-800-2
MDL number:
MFCD00009436
UNSPSC Code:
12352100
PubChem Substance ID:
24849766
NACRES:
NA.22

vapor density

9.2 (vs air)

Quality Level

300

vapor pressure

27 mmHg ( 178 °C)
7.3 mmHg ( 150 °C)

assay

97%

form

liquid

autoignition temp.

770 °F

refractive index

n20/D 1.424 (lit.)

bp

180-183 °C/22 mmHg (lit.)

mp

−79 °C (lit.)

solubility

water: soluble 1ml in 165ml water
organic solvents: miscible

density

0.979 g/mL at 25 °C (lit.)

functional group

phosphate

SMILES string

CCCCOP(=O)(OCCCC)OCCCC

InChI

1S/C12H27O4P/c1-4-7-10-14-17(13,15-11-8-5-2)16-12-9-6-3/h4-12H2,1-3H3

InChI key

STCOOQWBFONSKY-UHFFFAOYSA-N

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General description

Tributyl phosphate (TBP) is an organophosphorus compound widely used as a solvent in nuclear fuel reprocessing for the extraction of uranium and plutonium from other radionuclides.
Tributyl phosphate is an endocrine disrupting compound.

Application

Tributyl phosphate was employed as:
  • solvent in the solvent-detergent method for production of immunoglobulin for inactivation of viruses with lipid envelope on the model of duck hepatitis B virus
  • ligand in the extraction of lanthanide ions from solid and liquid materials by supercritical CO2
  • extractant for metal complexes

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

293.0 °F - closed cup

flash_point_c

145 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW4386
MKCV8577
STBK3689
MKCJ8659
STBL1040

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Analytica Chimica Acta, 71, 85-85 (1974)
Supercritical fluid extraction of lanthanides with fluorinated. beta.-diketones and tributyl phosphate.
Lin Y and Wai CM.
Analytical Chemistry, 66(13), 1971-1975 (1994)
N V Zubkova et al.
Bulletin of experimental biology and medicine, 155(6), 821-824 (2013-11-30)
The virucidal action of solvent tributyl phosphate and detergent sodium cholate used in the production of immunoglobulin for inactivation of viruses with lipid envelope was studied on the model of duck hepatitis B virus. PCR analysis revealed no significant decrease
Hans Christian Winkler et al.
Particle and fibre toxicology, 14(1), 21-21 (2017-06-25)
Dendritic cells (DCs) are specialized first-line sensors of foreign materials invading the organism. These sentinel cells rely on pattern recognition receptors such as Nod-like or Toll-like receptors (TLRs) to launch immune reactions against pathogens, but also to mediate tolerance to
Biodegradation of tributyl phosphate by naturally occurring microbial isolates and coupling to the removal of uranium from aqueous solution.
Thomas R A and Macaskie L E
Environmental Science & Technology, 30(7), 2371-2375 (1996)
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