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137111

Sigma-Aldrich

Ethoxyacetic acid

98%

Synonym(s):

O-Ethylglycolic acid

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About This Item

Linear Formula:
C2H5OCH2COOH
CAS Number:
627-03-2
Molecular Weight:
104.10
Beilstein/REAXYS Number:
1743037
EC Number:
210-978-2
MDL number:
MFCD00004310
UNSPSC Code:
12352100
PubChem Substance ID:
24848312
NACRES:
NA.22

assay

98%

refractive index

n20/D 1.419 (lit.)

bp

97-100 °C/11 mmHg (lit.)

density

1.102 g/mL at 25 °C (lit.)

functional group

carboxylic acid
ether

SMILES string

CCOCC(O)=O

InChI

1S/C4H8O3/c1-2-7-3-4(5)6/h2-3H2,1H3,(H,5,6)

InChI key

YZGQDNOIGFBYKF-UHFFFAOYSA-N

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General description

Ethoxyacetic acid is biomarker of exposure to widely used industrial chemicals such as alkyl-substituted ethylene glycols and other aliphatic ethers[1].

Application

Ethoxyacetic acid is metabolite of glycol ether alkoxy acid and was used to evaluate its toxicity in embryonic stem cell test in mouse[2]. It was used in zebrafish embryotoxicity test to study chemical toxicity after exposure of the complete vertebrate embryo during embryogenesis in ovo[3].

Biochem/physiol Actions

Ethoxyacetic acid induces testicular toxicity in rats in vivo [4].

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

206.6 °F - closed cup

flash_point_c

97 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCS9283
SHBJ5874
SHBH9063
SHBG7444V
BCBB1437V

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L Aasmoe et al.
Xenobiotica; the fate of foreign compounds in biological systems, 27(12), 1237-1244 (1998-02-14)
1. The elimination of 2-methoxyethanol (2-ME) and its toxic metabolite methoxyacetic acid (MAA) was studied in the male and female rat. We also studied the elimination of ethoxyacetic acid (EAA), the toxic metabolite formed by 2-ethoxyethanol (2-EE). 2. The rate
T S Shih et al.
Occupational and environmental medicine, 56(7), 460-467 (1999-09-03)
To simplify the current preparation of samples, and to improve the specificity and reliability of the conventional analytical methods to measure urinary alkoxyacetic acids. Samples containing alkoxyacetic acids including methoxy, ethoxy, and butoxyacetic acids (MAA, EAA, and BAA) were acidified
Esther de Jong et al.
Toxicological sciences : an official journal of the Society of Toxicology, 110(1), 117-124 (2009-04-30)
The embryonic stem cell test (EST) has been proposed as an in vitro assay that might reduce animal experimentation in regulatory developmental toxicology. So far, evaluation of the EST was not performed using compounds within distinct chemical classes. Evaluation within
L Aasmoe et al.
Xenobiotica; the fate of foreign compounds in biological systems, 29(4), 417-424 (1999-06-22)
1. The pharmacokinetics of methoxyacetic acid (MAA) and ethoxyacetic acid (EAA) have been determined in the male and female rat following bolus intravenous administration at 100 mg/kg. The plasma-concentration data of MAA fitted well to a one-compartment model, and the
H Veulemans et al.
British journal of industrial medicine, 50(1), 71-78 (1993-01-01)
A case-control study was conducted among first time patients at a clinic for reproductive disorders. The study group consisted of 1019 cases, defined as patients diagnosed infertile or subfertile on the basis of a spermiogram and 475 controls who were
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