116327

2-Chloro-4-methylpyridine

98%

• Synonym(s): 2-Chloro-4-picoline
• Empirical Formula (Hill Notation): C₆H₆ClN
• CAS Number: 3678-62-4
• Molecular Weight: 127.57
• EC Number: 222-951-2
• MDL number: MFCD00023418
• UNSPSC Code: 12352100
• PubChem Substance ID: 24847284
• NACRES: NA.22

Properties

• assay: 98%
• refractive index: n20/D 1.529 (lit.)
• bp: 194-195 °C (lit.)
• density: 1.142 g/mL at 25 °C (lit.)
• SMILES string: Cc1ccnc(Cl)c1
• InChI: 1S/C6H6ClN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3
• InChI key: MZVSTDHRRYQFGI-UHFFFAOYSA-N

Description

General description

2-Chloro-4-methylpyridine (2-Chloro-4-picoline) reacts with 3,5-bis(trifluoromethyl)phenylboronic acid to form 2-(3,5-bis(trifluoromethyl)phenyl)-4-methylpyridine by palladium-catalyzed cross-coupling reaction.

2-Chloro-4-picoline (2-Chloro-4-methylpyridine) has been used in the determination of gas-phase basicity of several relatively small organic molecules that are used in the MALDI.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter