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116289

Sigma-Aldrich

4-Chloro-3-nitroanisole

98%

Synonym(s):

1-Chloro-4-methoxy-2-nitrobenzene

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About This Item

Linear Formula:
ClC6H3(NO2)OCH3
CAS Number:
10298-80-3
Molecular Weight:
187.58
Beilstein/REAXYS Number:
640872
EC Number:
233-674-1
MDL number:
MFCD00007077
UNSPSC Code:
12352100
PubChem Substance ID:
24847280
NACRES:
NA.22

assay

98%

mp

41-43 °C (lit.)

functional group

chloro

SMILES string

COc1ccc(Cl)c(c1)[N+]([O-])=O

InChI

1S/C7H6ClNO3/c1-12-5-2-3-6(8)7(4-5)9(10)11/h2-4H,1H3

InChI key

HISHUMDTGXICEZ-UHFFFAOYSA-N

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Application

4-chloro-3-nitroanisole is used to synthesize a group of derivatives of 7-methanesulfonylamino-6-phenoxychromone at the pyrone and phenoxy rings.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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T Inaba et al.
Chemical & pharmaceutical bulletin, 48(1), 131-139 (2000-03-08)
A group of derivatives of 7-methanesulfonylamino-6-phenoxychromone (1) at the pyrone and phenoxy rings was synthesized starting with 4-chloro-3-nitroanisole and evaluated against acute and chronic inflammations in oral administration in animals. Significant potency in the rat models of carrageenin-induced edema (CPE)

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