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107255

Sigma-Aldrich

3-Hydroxy-2-nitropyridine

97%

Synonym(s):

2-Nitro-3-pyridinol

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About This Item

Empirical Formula (Hill Notation):
C5H4N2O3
CAS Number:
15128-82-2
Molecular Weight:
140.10
EC Number:
239-191-2
MDL number:
MFCD00006258
UNSPSC Code:
12352100
PubChem Substance ID:
24846759

assay

97%

form

solid

mp

69-71 °C (lit.)

functional group

nitro

SMILES string

Oc1cccnc1[N+]([O-])=O

InChI

1S/C5H4N2O3/c8-4-2-1-3-6-5(4)7(9)10/h1-3,8H

InChI key

QBPDSKPWYWIHGA-UHFFFAOYSA-N

Application

3-Hydroxy-2-nitropyridine may be used in the synthesis of novel sulfonates that are potent inhibitors of cell proliferation and tubulin polymerization.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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S L Gwaltney et al.
Bioorganic & medicinal chemistry letters, 11(13), 1671-1673 (2001-06-27)
The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+) cancer cells, which are

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