1537003

Physostigmine salicylate

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): Eserine salicylate salt, Physostigmine salicylate salt
• Empirical Formula (Hill Notation): C₁₅H₂₁N₃O₂ · C₇H₆O₃
• CAS Number: 57-64-7
• Molecular Weight: 413.47
• Beilstein/REAXYS Number: 3900576
• MDL number: MFCD00135659
• UNSPSC Code: 41116107
• PubChem Substance ID: 329750836
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: physostigmine
• manufacturer/tradename: USP
• mp: 181-183 °C
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: OC(=O)c1ccccc1O.CNC(=O)Oc2ccc3N(C)[C@H]4N(C)CC[C@@]4(C)c3c2
• InChI: 1S/C15H21N3O2.C7H6O3/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2;8-6-4-2-1-3-5(6)7(9)10/h5-6,9,13H,7-8H2,1-4H3,(H,16,19);1-4,8H,(H,9,10)/t13-,15+;/m1./s1
• InChI key: HZOTZTANVBDFOF-PBCQUBLHSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Physostigmine salicylate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Physostigmine Salicylate Injection

Biochem/physiol Actions

Acetylcholinesterase inhibitor that crosses the blood-brain barrier and forms a carbamylated enzyme complex with acetyl cholinesterase that degrades slowly.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H300 + H330
• pcodes: P260 - P301 + P330 + P331 + P310 - P304 + P340 + P310 - P403 + P233
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable