821834

TOYOPEARL GigaCap^® S-650M Bulk Media

phase sulphonyl, bottle of 250 mL, 75 μm particle size

• Synonym(s): TOYOPEARL GigaCap^® S-650 Cation Exchange Media
• UNSPSC Code: 41115700

Properties

• product line: TOYOPEARL^®
• form: slurry
• feature: counter ion Na+
• packaging: bottle of 250 mL
• manufacturer/tradename: Tosoh 21834
• parameter: 3 bar max. pressure
• technique(s): LPLC: suitable
• matrix: hydroxylated methacrylic polymer
• matrix active group: sulphonyl phase
• particle size: 75 μm
• operating pH: 3-13
• capacity: 156 g/L±20 adsorption capacity (hIgG)
• separation technique: cation exchange

Description

General description

Toyopearl GigaCap S-650 resin is a high capacity, high resolution cation exchange resin* optimized for process scale applications, including the capture and purification of IgG as well as the polishing of monoclonal antibodies. A Toyopearl HW-65 polymeric bead has been chemically modified to provide a higher number of cationic binding sites for increased resin capacity.
While Toyopearl GigaCap S-650M resin was specifically optimized for IgG, with dynamic binding capacities in the vicinity of 140 mg/mL for IgG, it also exhibits high binding capacities for smaller proteins. Typical dynamic binding capacities for lysozyme are in excess of 160 mg/mL.
Toyopearl GigaCap S-650S resin has dynamic binding capacities approaching 165 g/L for gamma globulin. This high capacity, combined with the 35 μm mean particle size, makes Toyopearl GigaCap S-650S ideal for high resolution applications.
Toyopearl GigaCap S-650 resin is stable at high linear velocities, has good pressure-flow characteristics and will withstand back pressures up to 3 bar. The higher capacity and back pressure stability of Toyopearl GigaCap S-650 resin creates opportunities for increased throughput in downstream cation exchange purification steps.
Toyopearl GigaCap S-650M resin also has excellent base stability in 1.0 mol/L NaOH and shows robust clean in place (CIP) properties with minimal loss of capacity after 50 X 1 hour cycles of caustic exposure also using 1.0 mol/L NaOH. (data)
*specifically designed for packed bed use

Specifications

Clean in place with 0.5 M NaOH or 0.1 M HCl.

Physical form

72% (v/v) slurry in 20% (v/v) ethanol

Shipped in 20% (v/v) ethanol.

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Legal Information

Toyopearl is a registered trademark of Tosoh Corporation

Toyopearl GigaCap is a registered trademark of Tosoh Corporation

Safety Information

• pictograms: GHS02
• signalword: Warning
• hcodes: H226
• pcodes: P210 - P233 - P240 - P241 - P242 - P243
• Hazard Classifications: Flam. Liq. 3
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 104.0 °F - closed cup
• flash_point_c: 40 °C - closed cup