Hexabromocyclododecane (HBCD) is a high production volume brominated flame retardant (BFR) which has been of increasing environmental and public health concern due to its potential environmental persistency, bioaccumulation and toxicity. Tris-(2,3-dibromopropyl) isocyanurate (TBC) is another BFR which has recently been
Fundamental and applied toxicology : official journal of the Society of Toxicology, 23(3), 363-369 (1994-10-01)
Our laboratory has been examining the mechanisms whereby chemicals produce mutagenicity in short-term in vitro assays yet fail to produce carcinogenesis in 2-year rodent bioassays. Previous studies indicated that some mutagenic hepatocarcinogens increased cell proliferation in the target organ, the
Environmental and molecular mutagenesis, 28(4), 418-423 (1996-01-01)
The flame retardant tris(2,3-dibromopropyl)phosphate (TDBP), once used in cotton sleep wear for children, is presently banned from commerce. It produces tumors in rodents in both a sex- and tissue-specific manner. The kidney is the main target for tumor formation in
Mutation spectra recovered from lacI transgenic animals exposed in separate experiments to tris-(2,3-dibromopropyl)phosphate (TDBP) or aflatoxin B1 (AFB1) were examined using log-linear analysis. Log-linear analysis is a categorical procedure that analyses contingency table data. Expected contingency table cell counts are
Recently, oversulfated chondroitin sulfate (OSCS) was identified in contaminated heparin preparations, which were linked to several adverse clinical events and deaths. Orthogonal analytical techniques, namely nuclear magnetic resonance (NMR) and capillary electrophoresis (CE), have since been applied by several authors
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