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Methanolic HCl

0.5 M HCl in methanol (0.5N), for GC derivatization, ampule of 10 × 5 mL

Synonym(s):

Hydrogen chloride, Hydrochloric acid solution

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About This Item

Empirical Formula (Hill Notation):
HCl
CAS Number:
7647-01-0
Molecular Weight:
36.46
UNSPSC Code:
41116105
PubChem Substance ID:
24859924

grade

for GC derivatization

reaction suitability

reagent type: derivatization reagent
reaction type: Esterifications

packaging

ampule of 10 × 5 mL

concentration

0.5 M HCl in methanol (0.5N)

storage temp.

2-8°C

InChI

1S/ClH/h1H

InChI key

VEXZGXHMUGYJMC-UHFFFAOYSA-N

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General description

Methanolic HCl (hydrochloric acid in methanol) is particularly useful for preparing methyl esters of volatile (short chain) fatty acids. Fatty acids are esterified by heating them with an anhydrous alcohol (e.g., methanol) in the presence of an acidic catalyst (e.g., HCl) in a sealed vessel at a high temperature for a short time. In the reaction, a fatty acid molecule and an alcohol molecule are joined, with the release of a water molecule. The derivatives can be quickly and easily recovered, quantitatively, from the reaction medium.

Features and Benefits

  • Derivatization of fatty acids, particularly volatile (short chain) fatty acids.

  • Clean reaction (no side reaction) with volatile by-products.

  • Provides clean, fast, quantitative derivatization.

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signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - Met. Corr. 1 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

51.8 °F - closed cup

flash_point_c

11 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
LC22018V
LC21653V
LC19466V
LC16315V
LC13858V

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Sigma-Aldrich

455180

Hydrogen chloride solution

X Qiu et al.
The Journal of biological chemistry, 276(34), 31561-31566 (2001-06-09)
The existence of Delta 4 fatty acid desaturation in the biosynthesis of docosahexanoic acid (DHA) has been questioned over the years. In this report we describe the identification from Thraustochytrium sp. of two cDNAs, Fad4 and Fad5, coding for Delta
Practical Gas Chromatography: A Comprehensive Reference.
Wilder KD and Engewald W.
Science, 613-614 (2014)
Mitochondrial Function, Part B: Mitochondrial Protein Kinases, Protein Phosphatases and Mitochondrial Diseases.
William SA and Murphy AN.
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[Fluid and electrolyte movements through the gastrointestinal membranes: hydrochloric acid formation and intestinal water transport].
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Because pulmonary endogenous surfactant is altered during acute respiratory distress syndrome, surfactant replacement may improve clinical outcomes. However, trials of surfactant use have had mixed results. We designed this animal model of unilateral (right) lung injury to explore the effect
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