D6413
Diloxanide furoate
Synonym(s):
2,2-Dichloro-N-(4-hydroxyphenyl)-N-methylacetamide 2-furoic acid ester
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About This Item
Empirical Formula (Hill Notation):
C14H11Cl2NO4
CAS Number:
Molecular Weight:
328.15
UNSPSC Code:
51101500
PubChem Substance ID:
EC Number:
223-108-1
MDL number:
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InChI key
BDYYDXJSHYEDGB-UHFFFAOYSA-N
InChI
1S/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3
SMILES string
CN(C(=O)C(Cl)Cl)c1ccc(OC(=O)c2ccco2)cc1
antibiotic activity spectrum
parasites
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Asteria Luzardo Álvarez et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(1), 215-227 (2012-06-20)
We present a new strategy to suppress the attachment of Cryptosporidium parvum to the enterocytes cell surface by bioadhesive microspheres. An optimized microsphere system based on chitosan/poly(vinyl alcohol) was prepared by experimental design for the delivery of Diloxanide Furoate-cyclodextrin complex.
Julieta B Monteiro et al.
International journal of pharmaceutics, 267(1-2), 93-100 (2003-11-07)
In this study, we investigated the susceptibility to enzymatic and alkaline hydrolysis of diloxanide furoate (DF) and its cyclodextrin inclusion complexes, in aqueous solution. The cyclodextrins (CDs) utilized were beta-cyclodextrin (beta-CD), (2,6-di-O-methyl)-beta-cyclodextrin (DM-beta-CD) and (2,3,6-tri-O-methyl)-beta-cyclodextrin (TM-beta-CD). All cyclodextrins studied provided
E A Gadkariem et al.
Farmaco (Societa chimica italiana : 1989), 59(4), 323-329 (2004-04-15)
The degradation of the amoebicide diloxanide furoate in alkaline medium at different temperatures was investigated using both a spectrophotometric and a developed HPLC method. In solutions, the drug was found to undergo decomposition, i.e., temperature and pH dependent. The pH-rate
Esin Aki-Sener et al.
Farmaco (Societa chimica italiana : 1989), 57(6), 451-456 (2002-06-29)
The synthesis of some N-(2-hydroxy-4-substitutedphenyl)benzamides, phenylacetamides and furamides as the possible metabolites of benzoxazoles (II1-15) was performed in order to determine their in vitro antimicrobial activity against three Gram-positive bacteria, two Gram-negative bacteria and the fungus Candida albicans and their
Tsukasa Fujishima et al.
Chemotherapy, 56(4), 348-352 (2010-08-20)
A mass Entamoeba histolytica infection recurred despite repeated treatments with metronidazole at a rehabilitation institution for individuals with intellectual impairments. Diloxanide furoate was administered to improve intractable intestinal amoebiasis after a recurring amoebic infection that tends to occur via coprophagy
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