D6413

Diloxanide furoate

Name: Diloxanide furoate
Brand: SIGMA

Synonym(s):

2,2-Dichloro-N-(4-hydroxyphenyl)-N-methylacetamide 2-furoic acid ester

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₁Cl₂NO₄

CAS Number:

3736-81-0

Molecular Weight:

328.15

UNSPSC Code:

51101500

PubChem Substance ID:

24894026

EC Number:

223-108-1

MDL number:

MFCD00083302

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Key Documents

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antibiotic activity spectrum

parasites

SMILES string

CN(C(=O)C(Cl)Cl)c1ccc(OC(=O)c2ccco2)cc1

InChI

1S/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3

InChI key

BDYYDXJSHYEDGB-UHFFFAOYSA-N

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

080H0180

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Difficulties in the treatment of intestinal amoebiasis in mentally disabled individuals at a rehabilitation institution for the intellectually impaired in Japan.

Tsukasa Fujishima et al.

Chemotherapy, 56(4), 348-352 (2010-08-20)

A mass Entamoeba histolytica infection recurred despite repeated treatments with metronidazole at a rehabilitation institution for individuals with intellectual impairments. Diloxanide furoate was administered to improve intractable intestinal amoebiasis after a recurring amoebic infection that tends to occur via coprophagy

Simultaneous amoebic liver abscess and hepatitis A infection.

E Schwartz et al.

Journal of travel medicine, 5(2), 95-96 (1998-10-17)

Hepatitis A virus (HAV) infection and amoebic liver abscess have an identical mode of transmission (fecal-oral route) and similar epidemiology. Either of these diseases might be considered in patients presenting with clinical signs and symptoms of liver disease in areas

Treatment of asymptomatic intestinal Entamoeba histolytica infection.

Joerg Blessmann et al.

The New England journal of medicine, 347(17), 1384-1384 (2002-10-25)

Cecal ameboma.

Deepak Joshi et al.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 8(1), A28-A28 (2009-03-14)

Simultaneous determination of diloxanide furoate and metronidazole in presence of diloxanide furoate degradation products.

Samah S Abbas et al.

Journal of AOAC International, 94(5), 1427-1439 (2011-12-15)

Three methods are presented for the simultaneous determination of diloxanide furoate (DLX) and metronidazole (MTR), used for their antiprotozoal and antiamoebic effect, in the presence of DLX alkaline degradates and in pharmaceutical formulations, without previous separation. The first method is

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