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Z701807

High Throughput Bioanalytical Sample Preparation

D. Wells, Elsevier Health Sciences, 2002, 628 pp., hard cover

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About This Item

ISBN-10:
0-444-51029-X
ISBN-13:
978-0-444-51029-7
UNSPSC Code:
55101509

publication info

D. Wells, Elsevier Health Sciences, 2002, 628 pp., hard cover

manufacturer/tradename

Elsevier

General description

This book is a reference on state-of-the-art sample preparation techniques for bioanalysis. It focuses on high throughput techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A review of the literature is included within each of these chapters: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line techniques. Objectives that can be accomplished when the presented strategies are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods and return on investment in automation for sample preparation.

Table of Contents

Role of Bioanalysis in Pharmaceutical Drug Development.
Fundamental Strategies for Bioanalytical Sample Preparation.
High Throughput Tools for Bioanalysis: Microplates.
High Throughput Tools for Bioanalysis: Accessory Products.
Automation Tools and Strategies for Bioanalysis.
Protein Precipitation: High Throughput Techniques and Strategies for Method Development.
Protein Precipitation: Automation Strategies.
Liquid-Liquid Extraction: High Throughput Techniques. .
Liquid-Liquid Extraction: Strategies for Method Development and Optimization.
Liquid-Liquid Extraction: Automation Strategies.
Solid-Phase Extraction: High Throughput Techniques.
Solid-Phase Extraction: Strategies for Method Development and Optimization.
Solid-Phase Extraction: Automation Strategies. .
On-Line Sample Preparation: High Throughput Techniques and Strategies for Method Development.
Advances in Sample Preparation for Bioanalysis.

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