Z3402
14-3-3 Zeta, histidine-tagged human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
14-3-3 protein Zeta, KCIP-1, Protein kinase C inhibitor protein 1, YWHAZ
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About This Item
UNSPSC Code:
12352200
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
buffered aqueous glycerol solution
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... YWHAZ(7534)
Application
14-3-3 Zeta, histidine-tagged human was used to study its role in regulating the von Willebrand factor (VWF) binding functions of GPIb-IX. Zeta isoform of 14-3-3 protein facilitated the formation of human tau fibrillar polymers.[1]
Biochem/physiol Actions
14-3-3 ζ functions in cell signaling, cell cycle control, and apoptotic death.
14-3-3 protein is an adapter protein that inhibits apoptosis as well as differentially regulates MAPK cascades.[2] It facilitates the regulation of several cellular processes like- cell-cycle control, apoptosis, stress response and malignant transformation.[3]
The 14-3-3 proteins are a multifunctional protein family comprising seven mammalian isoforms that interact with over two hundred different intracellular molecules including kinases, phosphatases, transcription factors, scaffold proteins, and DNA. 14-3-3 proteins are linked to many human diseases. 14-3-3 ζ functions in cell signaling, cell cycle control, and apoptotic death. 14-3-3 ζ interacts with β-catenin and facilitates its activation by AKT. 14-3-3 ζ plays an important role in regulating von Willebrand factor (VWF) binding the function of GPIb-IX suggesting a role in preventing or treating thrombosis. 14-3-3 ζ is involved in various types of cancer as a prognostic and therapeutic target and also involved in Alzheimer′s disease.
Physical form
Supplied as a 0.2 μm filtered solution in 50 mM Tris, pH 7.6, with 1 mM EDTA, 1 mM DTT, and 20% (w/v) glycerol.
related product
Product No.
Description
Pricing
Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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M J van Hemert et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 23(10), 936-946 (2001-10-13)
The 14-3-3 proteins constitute a family of conserved proteins present in all eukaryotic organisms so far investigated. These proteins have attracted interest because they are involved in important cellular processes such as signal transduction, cell-cycle control, apoptosis, stress response and
H Xing et al.
The EMBO journal, 19(3), 349-358 (2000-02-02)
14-3-3 family members are dimeric phosphoserine-binding proteins that participate in signal transduction and checkpoint control pathways. In this work, dominant-negative mutant forms of 14-3-3 were used to disrupt 14-3-3 function in cultured cells and in transgenic animals. Transfection of cultured
Félix Hernández et al.
Neuroscience letters, 357(2), 143-146 (2004-03-24)
Tau protein can aggregate, in an aberrant way, in Alzheimer's disease and other tauopathies. The formation of those aggregates could take place in vitro by the addition of different compounds like polyanions or fatty acids and their derivates. Now, we
Anne Kistner et al.
Rheumatology (Oxford, England), 56(5), 829-834 (2017-01-09)
Autoantibodies are useful biomarkers for diagnosing and monitoring treatment in some autoimmune diseases. Antibodies against isoforms of 14-3-3 protein have been proposed as biomarkers for the presence of aortic aneurysm in large-vessel vasculitis (LVV). Here, we aimed to evaluate the
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