Y1521

YS-49 monohydrate

≥98% (HPLC)

• Synonym(s): 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate
• Empirical Formula (Hill Notation): C₂₀H₁₉NO₂ · HBr · H₂O
• CAS Number: 132836-42-1
• Molecular Weight: 404.30
• MDL number: MFCD16875442
• UNSPSC Code: 12352200
• PubChem Substance ID: 329831588
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: solid
• solubility: H₂O: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.Br.Oc1cc2CCNC(Cc3cccc4ccccc34)c2cc1O
• InChI: 1S/C20H19NO2.BrH.H2O/c22-19-11-15-8-9-21-18(17(15)12-20(19)23)10-14-6-3-5-13-4-1-2-7-16(13)14;;/h1-7,11-12,18,21-23H,8-10H2;1H;1H2
• InChI key: QHCUNMLYODPTIU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

YS-49 protects cells from oxidant injury; anti-inflammatory agent; activator of PI3K/Akt signaling. YS-49, an analog of higenamine, induces heme oxygenase (HO-1) in endothelial cells and protects cells from oxidant injury. The compound was reported to inhibit Ang II-stimulated VSMC proliferation through HO-1 production, which inhibits both the JNK pathway and ROS production. A study (JPET) reported that CKD712 (S-YS-49) confer cardiac protection and anti-inflammatory via activation of the PI3K signal pathway. These effects were antagonized by a PI3K inhibitor, wortmannin.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable