Y0271

Anti-YB-1 (N-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-BP-8, Anti-CSDA2, Anti-CSDB, Anti-DBPB, Anti-MDR-NF1, Anti-NSEP1, Anti-Y BOX binding protein 1, Anti-YBOX1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~50 kDa (An additional weaker band may be seen in some extract preparations.)
• species reactivity: mouse, rat, human
• concentration: ~1 mg/mL
• technique(s): western blot: 0.5-1 μg/mL using PC-12 cell lysates; western blot: 1-2 μg/mL using HEK-293T or NIH-3T3 cell lysates
• UniProt accession no.: P67809
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... YBX1(4904) ; mouse ... Ybx1(22608) ; rat ... Ybx1(500538)

Description

General description

YB-1 (Y-box-binding protein 1) is a member of the evolutionary conserved Cold-Sock Domain (CSD) proteins. It is ubiquitously expressed in adult tissues and throughout embryogenesis.

Immunogen

synthetic peptide corresponding to amino acidds 137-150 of human YB-1, conjugated to KLH. The corresponding sequence is identical in rat and mouse proteins.

Application

Anti-YB-1 (N-terminal) antibody has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

YB-1 (Y-box-binding protein 1) plays a major role in a wide variety of cellular functions such as transcriptional and translation regulation, DNA repair, drug resistance and stress responses. YB-1 deficient embryos die during late embryonic development and exhibit a runting phenotype.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)