This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. (provided by RefSeq)
Immunogen
HES5 (NP_001010926, 28 a.a. ~ 121 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Hes family bHLH transcription factor 5 (HES5) is a regulator of Wnt family member 3A (Wnt-3A) protein. It is involved in stimulating the proliferation and differentiation of hepatocellular carcinoma cells. Methylation of the HES5 promoter has been studied to have a link with prostate cancer.
Physical form
Solution in phosphate buffered saline, pH 7.4
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
HES5 silencing is an early and recurrent change in prostate tumourigenesis.
Massie CE
Endocrine-Related Cancer, 22(2), 131-144 (2015)
HES5 promotes cell proliferation and invasion through activation of STAT3 and predicts poor survival in hepatocellular carcinoma.
Zhu G
Experimental and Molecular Pathology, 99(3), 474-484 (2015)
HES5 is a key mediator of Wnt-3a-induced neuronal differentiation.
Mubmann C
Stem Cells and Development, 23(12), 1328-1339 (2014)
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