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Key Documents

WH0085313M1

Sigma-Aldrich

Monoclonal Anti-PPIL4 antibody produced in mouse

clone 1C10, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-HDCME13P, Anti-peptidylprolyl isomerase (cyclophilin)-like 4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1C10, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL

isotype

IgG2aκ

GenBank accession no.

NM_139126

UniProt accession no.

Q8WUA2

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PPIL4(85313)

General description

Peptidylprolyl isomerase like 4 (PPIL4) is part of the cyclophilin family. This family has a role in protein folding, human immunodeficiency virus-1 (HIV-1) infection and immunosuppression by cyclosporin A. The gene encoding PPIL4 is localized on human chromosome 6q24-->q25. It possesses a PPIase motif, a lysine-rich domain, a RNA recognition motif and two bipartite nuclear targeting sequences. PPIL4 is expressed in the kidneys and other tissues.

Immunogen

PPIL4 (NP_624311, 395 a.a. ~ 466 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
EKEDEDYMPIKNTNQDIYREMGFGHYEEEESCWEKQKSEKRDRTQNRSRSRSRERDGHYSNSHKSKYQTDLY

Biochem/physiol Actions

Peptidylprolyl isomerase like 4 (PPIL4) may have a role in the immune system. Polymorphisms in the PPIL4 gene may enhance inflammation during rheumatoid arthritis.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
07110-1C10

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Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain.
Zeng L
Cytogenetics and Cell Genetics (2001)
Simultaneous genome-wide association studies of anti-cyclic citrullinated peptide in rheumatoid arthritis using penalized orthogonal-components regression
Yanzhu Lin
BMC Proceedings (2009)

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