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Key Documents

WH0051463M1

Sigma-Aldrich

Monoclonal Anti-GPR89 antibody produced in mouse

clone 4D8, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-AL844549.1, Anti-G protein-coupled receptor 89, Anti-SH120

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4D8, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable

isotype

IgG2bκ

GenBank accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... GPR89B(51463)

General description

G protein-coupled receptor 89 (GPR89) is expressed in the Golgi apparatus. The gene encoding this multi-transmembrane protein is localized on human chromosome 1q21.2.

Immunogen

GPR89 (AAH03187, 175 a.a. ~ 284 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
SYFLRNVTDTDILALERRLLQTMDMIISKKKRMAMARRTMFQKGEVHNKPSGFWGMIKSVTTSASGSENLTLIQQEVDALEELSRQLFLETADLYATKERIEYSKTFKGK

Biochem/physiol Actions

G protein-coupled receptor 89 (GPR89) possesses a voltage-dependent anion-channel activity. It modulates Golgi function and regulates acidification.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.
Maeda Y
Nature Cell Biology, 10(10), 1135-1145 (2008)
DUF1220-Domain Copy Number Implicated in Human Brain-Size Pathology and Evolution
Laura J.Dumas
Africa Journal of Animal and Biomedical Sciences, 91(3) (2012)

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