Skip to Content
MilliporeSigma
All Photos(5)

Key Documents

WH0010797M1

Sigma-Aldrich

Monoclonal Anti-MTHFD2 antibody produced in mouse

clone 4G7-2G3, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-NMDMC, Anti-methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

Sign Into View Organizational & Contract Pricing

Select a Size

100 μG
$425.00

$425.00

Ships within 2 weeks. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)
Notify Me

Get notified when this item is ready to ship via email.

All Photos(5)

Select a Size

Change View
100 μG
$425.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$425.00

Ships within 2 weeks. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)
Notify Me

Get notified when this item is ready to ship via email.

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4G7-2G3, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG2aκ

GenBank accession no.

BC001548

UniProt accession no.

P13995

shipped in

dry ice

Storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MTHFD2(10797)

General description

Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 (MTHFD2) is a mitochondrial bifunctional enzyme. It possesses a methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase domain. The gene encoding this protein is localized on human chromosome 2p13.1.

Immunogen

MTHFD2 (AAH01548, 16 a.a. ~ 344 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
SLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN

Biochem/physiol Actions

Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 (MTHFD2) facilitates the regulation of breast cancer cell migration and invasion. MTHFD2 is involved in mitochondrial one-carbon folate metabolism. Decrease in MTHFD2 expression leads to impairment of cell migration and invasion into extracellular matrix and reduces the cell fraction with a high CD44 expression.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
IB121S1
D5241-S1
D2271-S1
DB061-S1
D9301-S1

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion
Oncotarget (2013)
The Folate Pathway and Nonsyndromic Cleft Lip and Palate
Susan H. Blanton
Birth Defects Research Part A: Clinical and Molecular Teratology, 91(1) (2011)
Targeting MTHFD2 in acute myeloid leukemia
Yana Pikman
The Journal of Experimental Medicine (2016)

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service