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WH0010247M1

Sigma-Aldrich

Monoclonal Anti-HRSP12 antibody produced in mouse

clone 2B8, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-P14.5, Anti-PSP, Anti-UK114, Anti-heat-responsive protein 12

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2B8, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunofluorescence: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG1κ

GenBank accession no.

BC010280

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HRSP12(10247)

General description

HRSP12 (Heat-responsive protein 12) is a trichloroacetic acid soluble protein belonging to the hypothetical family of small proteins, termed as YER057c/YJGF family. It has a molecular weight of 14.5kDa. It is expressed in monocytes, liver and kidney tumor cells. Its high level of expression has been reported in fully differentiated monocytes.

Immunogen

HRSP12 (AAH10280.1, 1 a.a. ~ 137 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MSSLIRRVISTAKAPGAIGPYSQAVLVDRTIYISGQIGMDPSSGQLVSGGVAEEAKQALKNMGEILKAAGCDFTNVVKTTVLLADINDFNTVNEIYKQYFKSNFPARAAYQVAALPKGSRIEIEAVAIQGPLTTASL

Biochem/physiol Actions

HRSP12 (Heat-responsive protein 12) mainly acts as a translational inhibitor protein. It has been proposed that the protein may have the potentiality to perform in various cellular mechanisms such as a differentiation-dependent regulation of protein synthesis in hepatocytes, renal tubular epithelial cells, smooth muscle cells and mononuclear phagocytes (MNP).

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

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Crystal structure of Homo sapiens protein hp14.5.
Babu A Manjasetty et al.
Proteins, 54(4), 797-800 (2004-03-05)
G Schmiedeknecht et al.
European journal of biochemistry, 242(2), 339-351 (1996-12-01)
A trichloroacetic-acid-soluble 14.5-kDa protein (p14.5) has been isolated from human mononuclear phagocytes (MNP) by a combination of trichloroacetic acid extraction, preparative electrophoresis and hydrophobic affinity chromatography; five tryptic peptides were subjected to protein sequencing. The full-length cDNA of the protein

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