The maternal embryonic leucine zipper kinase (MELK) is a member of the CAMK serine/threonine protein kinase superfamily. It is expressed at high level in oocytes, spermatogonia and embryos. This gene is mapped to human chromosome 9p13.
Immunogen
MELK (AAH14039, 550 a.a. ~ 650 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
The maternal embryonic leucine zipper kinase (MELK) prevents HIV-1 (human immunodeficiency virus) replication. It participates in cell cycle, cytokinesis, mRNA splicing and apoptosis. MELK also plays an important role in the development of germ cells.
Physical form
Solution in phosphate buffered saline, pH 7.4
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Phosphorylation of the HIV-1 capsid by MELK triggers uncoating to promote viral cDNA synthesis
Takeuchi H, et al.
PLoS Pathogens (2017)
MELK (maternal embryonic leucine zipper kinase)
Tassan JP
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2012)
Identification of IL11RA and MELK amplification in gastric cancer by comprehensive genomic profiling of gastric cancer cell lines
Calcagno DQ, et al.
World Journal of Gastroenterology, 22(43), 9506-9514 (2016)
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