RAD51 paralog C (RAD51C) is a tumor suppressor gene. It belongs to the RAD51-like gene family and the gene encoding it is localized on human chromosome 17q23.
Immunogen
RAD51C (AAH00667.1, 1 a.a. ~ 134 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
RAD51 paralog C (RAD51C) aids in the recruitment of the enzyme RAD51 to DNA break sites. It may be involved in modulating its translocation from the cytoplasm to the nucleus. RAD51C has a role in genomic stability and homologous recombination repair. It has been associated with breast and ovarian cancer. Mutations in the gene encoding RAD51C have been linked to Fanconi anemia.
Physical form
Solution in phosphate buffered saline, pH 7.4
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Estrogen induces RAD51C expression and localization to sites of DNA damage.
Alayev A
Cell Cycle (2016)
High expression of Rad51c predicts poor prognostic outcome and induces cell resistance to cisplatin and radiation in non-small cell lung cancer.
Chen X
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine (2016)
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