Chromodomain helicase DNA binding protein 3 (CHD3) is encoded by the gene mapped to human chromosome 17p13.1.The encoded protein belongs to the class II CHD protein family. CHD3 contains a pair of N-terminal plant homeodomain zinc fingers domains involved in chromatin-based transcriptional regulation.
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. (provided by RefSeq)
Immunogen
CHD3 (NP_001005273, 1654 a.a. ~ 1741 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Chromodomain helicase DNA binding protein 3 (CHD3)/CHD4 is an essential element of nucleosome remodeling and deacetylase (NuRD) complex, which plays a crucial role in synapse formation and heart development. It also has an essential role in mediating transcriptional repression of several infecting viral genomes, including herpesvirus. Deletion or downregulated expression of the gene has been associated with breast cancer.
Physical form
Solution in phosphate buffered saline, pH 7.4
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Chromodomain helicase DNA binding proteins (CHDs) are characterized by N-terminal tandem chromodomains and a central adenosine triphosphate-dependent helicase domain. CHDs govern the cellular machinery's access to DNA, thereby playing critical roles in various cellular processes including transcription, proliferation, and DNA
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