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Key Documents

COO/COA

WH0000650M2

Monoclonal Anti-BMP2 antibody produced in mouse

Name: Monoclonal Anti-BMP2 antibody produced in mouse
Brand: SIGMA

clone 1A11, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-BMP2A, Anti-Bone Morphogenetic Protein 2

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About This Item

MDL number:

MFCD02095901

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1A11, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable

isotype

IgG2aκ

GenBank accession no.

NM_001200

UniProt accession no.

P12643

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... BMP2(650)

General description

BMP2 (bone morphogenetic protein 2) is expressed in heart, lung and dorsal aorta. It is mapped to human chromosome 20p12.3.

Immunogen

BMP2 (NP_001191, 283 a.a. ~ 396 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
QAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR

Biochem/physiol Actions

BMP2 (bone morphogenetic protein 2) plays a vital role in the activation of the autonomic lineage-specific basic−helix-loop-helix protein, MASH1. It also plays a key role in autonomic neurogenesis in neural crest stem cells in vitro. In addition to its osteogenic activity, BMP2 also participates in cardiac morphogenesis. Mutation in the BMP2 gene is associated with osteoporosis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number

07184-1A11

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Linkage of osteoporosis to chromosome 20p12 and association to BMP2

Styrkarsdottir U, et al.

PLoS Biology, 1(3), e69-e69 (2003)

BMP2 is required for early heart development during a distinct time period

Schlange, et al.

Mechanisms of Development, 91(1-2), 259-270 (2000)

Alternative neural crest cell fates are instructively promoted by TGF beta superfamily members

Shah NM, et al.

Cell, 85(3), 331-343 (1996)

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer

Tomlinson IPM, et al.

PLoS Genetics, 7(6), e1002105-e1002105 (2011)

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