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V7009

Sigma-Aldrich

[Arg8]-Vasotocin-Gly-Lys

≥97% (HPLC)

Synonym(s):

Hydrin 1′

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About This Item

Empirical Formula (Hill Notation):
C51H81N17O15S2
CAS Number:
148440-73-7
Molecular Weight:
1236.42
MDL number:
MFCD00237115
UNSPSC Code:
12352200
PubChem Substance ID:
329829060
NACRES:
NA.26

Product Name

[Arg8]-Vasotocin-Gly-Lys, ≥97% (HPLC)

assay

≥97% (HPLC)

UniProt accession no.

P01185

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(O)=O

InChI

1S/C51H81N17O15S2/c1-3-26(2)41-48(80)63-31(15-16-37(54)70)44(76)65-34(21-38(55)71)45(77)66-35(25-85-84-24-29(53)42(74)64-33(46(78)67-41)20-27-11-13-28(69)14-12-27)49(81)68-19-7-10-36(68)47(79)62-30(9-6-18-58-51(56)57)43(75)60-22-39(72)59-23-40(73)61-32(50(82)83)8-4-5-17-52/h11-14,26,29-36,41,69H,3-10,15-25,52-53H2,1-2H3,(H2,54,70)(H2,55,71)(H,59,72)(H,60,75)(H,61,73)(H,62,79)(H,63,80)(H,64,74)(H,65,76)(H,66,77)(H,67,78)(H,82,83)(H4,56,57,58)/t26-,29-,30-,31-,32-,33-,34-,35-,36-,41-/m0/s1

InChI key

YWRWVVYMJJBIRH-IWZJHKITSA-N

Gene Information

human ... AVP(551)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
075H0217

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Satomi Kohno et al.
General and comparative endocrinology, 132(3), 485-498 (2003-07-10)
In most amphibians, [Arg(8)] vasotocin (VT) has an antidiuretic effect that is coupled to the activation of adenylate cyclase. In contrast, mesotocin (MT) has a diuretic effect and acts via the inositol phosphate/calcium signaling pathway in amphibians. To further clarify
Y Ogushi et al.
The Journal of experimental biology, 213(2), 288-294 (2009-12-30)
The ventral pelvic skin of the tree frog Hyla japonica expresses two kinds of arginine vasotocin (AVT)-stimulated aquaporins (AQP-h2 and AQP-h3), which affect the capacity of the frog's skin to absorb water. As such, it can be used as a
Y Rouillé et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(14), 5272-5275 (1989-07-01)
From neurointermediate pituitary glands of Xenopus laevis and Rana esculenta, previously unreported peptides termed hydrins, active on water permeability of frog urinary bladder and frog skin (Brunn or "water-balance" effect), have been isolated and sequenced. These peptides seem to be
S Iwamuro et al.
Biochimica et biophysica acta, 1176(1-2), 143-147 (1993-03-10)
The neurohypophysis of Xenopus and that of Ranidae and Bufonidae contain hydrin 1 (vasotocinyl-Gly-Lys-Arg) and hydrin 2 (vasotocinyl-Gly), respectively. In order to test the aldosterone-releasing activity of arginine vasotocin (AVT) and hydrin 1, purification of these peptides from an acid-extract
Yuji Ogushi et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 299(5), R1150-R1162 (2010-09-03)
Regions of specialization for water absorption across the skin of Bufonid and Ranid anurans were identified by immunohistochemistry and Western blot analysis, using antibodies raised against arginine vasotocin (AVT)-stimulated aquaporins (AQPs) that are specific to absorbing regions of Hyla japonica.

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