V6633

VEGF Receptor-3 (Flt-4)/Fc Chimera from mouse

>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

• Synonym(s): Vascular Endothelial Growth Factor Receptor‑3
• MDL number: MFCD03101927
• UNSPSC Code: 12352202

Properties

• biological source: mouse
• recombinant: expressed in baculovirus infected Sf21 cells
• assay: >95% (SDS-PAGE)
• form: lyophilized powder
• mol wt: 110-120 kDa by SDS-PAGE (glycosylation); calculated mol wt ~84.5 kDa
• packaging: pkg of 1 mg
• storage condition: avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
• impurities: endotoxin, tested
• UniProt accession no.: P35917
• Storage temp.: −20°C
• Gene Information: mouse ... Flt4(14257)

Description

application

VEGF Receptor-3 (Flt-4)/Fc Chimera from mouse is a disulfide-linked homodimeric protein consist of VEGF Receptor-3 fused with6X histidine tagged Fc portion of human IgG1 by a polypeptide linker. It may be used as a specific marker for lymphatic vessels as well as plays a pivotal role in the development of the lymphatic vessel system. The product was used to study the novel technique for pharmacological manipulation of blood and lymphatic vascularization in cultured mouse embryos ex vivo.[1]

Biochem/physiol Actions

VEGF Receptor-3 (Flt-4) belongs to class III subfamily of RTKs and is expressed mainly in endothelial cells. VEGF Receptor-3 can block VEGF-C/D and inhibits lymphangiogenesis and lymphatic metastasis in orthotopic urinary bladder cancer (OUBC).[2]

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Analysis Note

The activity is measured by its ability to bind human VEGF-D.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable