V1260

VEGF Receptor-3 (Flt-4)/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

• Synonym(s): Vascular Endothelial Growth Factor Receptor‑3
• MDL number: MFCD03101927
• UNSPSC Code: 51111800

Properties

• biological source: human
• recombinant: expressed in NSO cells
• assay: >95% (SDS-PAGE)
• form: lyophilized powder
• mol wt: calculated mol wt ~112 kDa
• packaging: pkg of 50 μg
• storage condition: avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
• impurities: endotoxin, tested
• UniProt accession no.: P35916
• storage temp.: −20°C
• Gene Information: human ... FLT4(2324)

Description

Application

VEGF Receptor-3 (Flt-4)/Fc chimera human is a disulfide-linked homodimeric protein that consists of VEGF Receptor-3 fused with6X histidine tagged Fc portion of human IgG1 by a polypeptide linker. It may be used as a specific marker for lymphatic vessels as well as plays a pivotal role in the development of the lymphatic vessel system.

Biochem/physiol Actions

VEGF Receptor-3 (Flt-4) belongs to class III subfamily of RTKs and is expressed mainly in endothelial cells. VEGF Receptor-3 blocks VEGF-C/D and hence inhibits lymphangiogenesis and lymphatic metastasis in orthotopic urinary bladder cancer (OUBC).[1]

Physical form

Lyophilized from a 2 μm filtered solution in phosphate buffered saline.

Analysis Note

The binding affinity of recombinant VEGF R3 has not been determined. Its intended use is for western blot and ELISA standards.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable