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UC440

Sigma-Aldrich

Benzydamine N-oxide hydrogen maleate

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About This Item

Empirical Formula (Hill Notation):
C19H23N3O2·C4H4O4
CAS Number:
72962-60-8
Molecular Weight:
441.48
UNSPSC Code:
12161501
PubChem Substance ID:
329827669

form

solid

color

white to off-white

mp

94-95 °C

storage temp.

2-8°C

SMILES string

OC(=O)\C=C/C(O)=O.C[N+](C)([O-])CCCOc1nn(Cc2ccccc2)c3ccccc13

InChI

1S/C19H23N3O2.C4H4O4/c1-22(2,23)13-8-14-24-19-17-11-6-7-12-18(17)21(20-19)15-16-9-4-3-5-10-16;5-3(6)1-2-4(7)8/h3-7,9-12H,8,13-15H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

QFAFNBZWRXPMSY-BTJKTKAUSA-N

Application

Benzydamine N-oxide hydrogen maleate can be used for spectroscopic analyses.

Biochem/physiol Actions

CYP2C9 substrate

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
332-130-1
033M3901V
033M3901
332-130-1V
1435753

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A Kawaji et al.
Biochimica et biophysica acta, 1425(1), 41-46 (1998-11-14)
Benzydamine (BZY) N-oxidation mediated by flavin-containing monooxygenase (FMO) was evaluated in perfused brain and liver. Following 20 min of perfusion with modified Ringer solution, the infusion of BZY into brain or liver led to production of BZY N-oxide. BZY N-oxide
G A Baldock et al.
Journal of chromatography, 529(1), 113-123 (1990-07-13)
A simple, sensitive and selective method for the determination of benzydamine in human plasma and urine, and for benzydamine N-oxide in urine, has been developed using high-performance liquid chromatography in the reversed-phase mode. The limit of reliable determination of benzydamine
Yuuka Masuyama et al.
Drug metabolism and pharmacokinetics, 35(3), 274-280 (2020-04-20)
Flavin containing monooxygenases (FMOs) represent one of the predominant types of phase I drug metabolizing enzymes (DMEs), and thus play an important role in the metabolism of xeno- and endobiotics for the generation of their corresponding oxides. These oxides often
Can caffeine metabolism be used as an in-vivo probe for human flavin-containing monooxygenase activity?
A E Rettie et al.
Pharmacogenetics, 10(3), 275-277 (2000-05-10)
B Catanese et al.
Pharmacological research communications, 18(4), 385-403 (1986-04-01)
A method for the extraction and quantification of benzydamine and its metabolite N-oxide by liquid chromatography with fluorescence detection in plasma samples is described. This method has adequate sensitivity, specificity and is reproducible. The use of the extraction column allowed
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