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U8132

Sigma-Aldrich

[pGlu110]-Prepro-Urotensin II Fragment 110-123 rat

>98% (HPLC), solid

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About This Item

Empirical Formula (Hill Notation):
C77H102N18O20S2
Molecular Weight:
1663.87
MDL number:
MFCD03788024
UNSPSC Code:
12352200
NACRES:
NA.32

assay

>98% (HPLC)

form

solid

UniProt accession no.

Q9QZQ4

Storage temp.

−20°C

Gene Information

rat ... Uts2(29180)

Amino Acid Sequence

Glp-His-Gly-Thr-Ala-Pro-Glu-Cys-Phe-Trp-Lys-Tyr-Cys-Ile [Disulfide Bridge: 117-122]

Application

Rat [pGlu110]-Prepro-Urotensin II Fragment 110-123 may be used for cell biology, cell signaling and neuroscience studies.

Biochem/physiol Actions

Potent vasoconstrictor.
Rat Urotensin II is a neuroendocrine peptide that belongs to CRF family and possesses regionally-selective vasodilator impact on conscious rats.[1] It also induces potent vasoconstriction in humans in vivo.[2]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
091K1522

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S M Gardiner et al.
British journal of pharmacology, 132(8), 1625-1629 (2001-04-20)
The regional haemodynamic effects of rat or human urotensin II (U-II) 3, 30, 300 and 3000 pmol kg(-1), i.v.) were assessed in separate groups of conscious, unrestrained, male, Sprague-Dawley rats (n=8 in each). Rat and human U-II had similar effects.
Felix Böhm et al.
British journal of pharmacology, 135(1), 25-27 (2002-01-12)
The peptide urotensin II (U II) evokes potent vasoconstriction in non-human primates. In human blood vessels studied in vitro variable effects of U II are reported; vasoconstriction, vasodilatation or no response. It is therefore of importance to determine the vascular

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