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U6375

Sigma-Aldrich

Uridine 5′-monophosphate disodium salt

≥99%

Synonym(s):

5′-UMP-Na2, U 5′-P, UMP, Uridylic acid disodium salt

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About This Item

Empirical Formula (Hill Notation):
C9H11N2Na2O9P
CAS Number:
Molecular Weight:
368.15
Beilstein/REAXYS Number:
3582885
EC Number:
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.26

biological source

(chemical)

assay

≥99%

form

powder

storage temp.

−20°C

SMILES string

[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])([O-])=O)N2C=CC(=O)NC2=O

InChI

1S/C9H13N2O9P.2Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18);;/q;2*+1/p-2/t4-,6-,7-,8-;;/m1../s1

InChI key

KURVIXMFFSNONZ-WFIJOQBCSA-L

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General description

Uridine 5′-monophosphate is a pyrimidine mononucleotide. It is formed by decarboxylation of orotidine 5′-monophosphate. UMP is further converted to UTP (uridine 5′-triphosphate) using kinases.

Application

Uridine 5′-monophosphate disodium salt has been used to study the effect of pyrimidine synthesis inhibitor, 5-azacytidine, on cholesterol and lipid metabolism. It has been used to study the effect of nucleotides on growth of specific intestinal bacteria.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism.
Poirier S, et al.
The Journal of Biological Chemistry, 289, 18736-18751 (2014)
Adams RLP, et al.
The Biochemistry of the Nucleic Acids (2013)
Nucleotides modify growth of selected intestinal bacteria in vitro.
Sauer N, et al.
Livestock Science, 133, 161-163 (2010)
Stefanie Bäurer et al.
Journal of chromatography. A, 1560, 45-54 (2018-05-24)
Herein, we present a novel silica-based stationary phase modified with N-propyl-N'-2-pyridylurea selector. Due to the weakly basic properties of the pyridine selector and the presence of residual silanols after selector immobilization, a zwitterionic surface with a pI observed at approximately
Willem Kasper Spoelstra et al.
Langmuir : the ACS journal of surfaces and colloids, 36(8), 1956-1964 (2020-01-30)
Coacervates are polymer-rich droplets that form through liquid-liquid phase separation in polymer solutions. Liquid-liquid phase separation and coacervation have recently been shown to play an important role in the organization of biological systems. Such systems are highly dynamic and under

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