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T9827

Sigma-Aldrich

TYRO3 (455-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

BYK, Brt, Dtk, RSE, Sky, Tif

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About This Item

UNSPSC Code:
12352200

recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

131-178 nmol/min·mg

mol wt

~77 kDa

UniProt accession no.

Q06418

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... TYRO3(7301)

Application

TYRO3 (455-end), active, GST tagged human is a member of Tyrosine protein kinase family and plays a pivotal role in many physiological processes like- spermatogenesis, immunoregulation, and phagocytosis. TYRO3 interacts with murine Gas6 and plays an essential role in arterial thrombus formation.

Biochem/physiol Actions

TYRO3 receptor protein tyrosine kinase together with AXL and MER form the AXL/TYRO3 family of receptor tyrosine kinases. Members of this family play an essential role in spermatogenesis, immunoregulation, and phagocytosis. In addition to signal transduction, members of this family of receptor tryrosine kinases participate in cell adhesion. Gas6, a product of growth arrest-specific gene, activates the kinase activity of all three receptors. TYRO3 is expressed in the brain (where it is involved in the protection of neurons from apoptosis), expressed in lymphoid, vascular and reproductive tissue and in primary and tumor cell lines. Members of the Tyro3 receptor tyrosine kinase family like-dtk facilitate the cell entry of Ebola and Marburg Viruses.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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J M E M Cosemans et al.
Journal of thrombosis and haemostasis : JTH, 8(8), 1797-1808 (2010-06-16)
Interaction of murine Gas6 with the platelet Gas6 receptors Tyro3, Axl and Mer (TAM) plays an important role in arterial thrombus formation. However, a role for Gas6 in human platelet activation has been questioned. To determine the role of Gas6
Receptor tyrosine kinase gene Tyro3 maps to mouse chromosome 2, closely linked to Ltk.
X Liao et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 7(5), 395-396 (1996-05-01)
Anne Angelillo-Scherrer et al.
The Journal of clinical investigation, 115(2), 237-246 (2005-01-15)
Mechanisms regulating thrombus stabilization remain largely unknown. Here, we report that loss of any 1 of the Gas6 receptors (Gas6-Rs), i.e., Tyro3, Axl, or Mer, or delivery of a soluble extracellular domain of Axl that traps Gas6 protects mice against
Masayuki Shimojima et al.
Journal of virology, 80(20), 10109-10116 (2006-09-29)
Filoviruses, represented by the genera Ebolavirus and Marburgvirus, cause a lethal hemorrhagic fever in humans and in nonhuman primates. Although filovirus can replicate in various tissues or cell types in these animals, the molecular mechanisms of its broad tropism remain

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