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T9444

Sigma-Aldrich

TECK from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym(s):

Thymus-expressed chemokine

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About This Item

MDL number:
MFCD01868673
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

mouse

recombinant

expressed in E. coli

assay

>97% (SDS-PAGE)

form

lyophilized powder

potency

0.66 μg/mL

mol wt

16-17 kDa by SDS-PAGE (doublet)
predicted mol wt ~14 kDa

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

UniProt accession no.

Q02858

storage temp.

−20°C

Gene Information

mouse ... Ccl25(20300)

Application

The interaction of TECK and its receptor CCR9 plays a pivotal role in recruiting the developing thymocytes to their distinct compartment of the thymus.[1]

Biochem/physiol Actions

TECK, a CC chemokine, is chemotactic for activated macrophages, dendritic cells, and thymocytes.
Thymus-expressed chemokine (TECK) belongs to CC chemokine and is expressed mainly in thymus and small intestine. It can facilitate chemotaxis of human G protein-coupled receptor GPR-9-6/L1.2 transfectants.[2] Further, TECK potentially assists in T Cell Development.[3]

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing at least 50 μg bovine serum albumin per 1 μg of cytokine.

Analysis Note

The biological activity is measured by its ability to chemoattract hCCR9 transfected BaF/3 cells.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
037K1428
027K1039
101K0319

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M A Wurbel et al.
European journal of immunology, 30(1), 262-271 (1999-12-22)
Chemokines are key regulators of migration in lymphoid tissues. In the thymus, maturing thymocytes move from the outer capsule to the inner medulla and thereby interact with different types of stromal cells that control their maturation and selection. In the
B A Zabel et al.
The Journal of experimental medicine, 190(9), 1241-1256 (1999-11-02)
TECK (thymus-expressed chemokine), a recently described CC chemokine expressed in thymus and small intestine, was found to mediate chemotaxis of human G protein-coupled receptor GPR-9-6/L1.2 transfectants. This activity was blocked by anti-GPR-9-6 monoclonal antibody (mAb) 3C3. GPR-9-6 is expressed on
A P Vicari et al.
Immunity, 7(2), 291-301 (1997-08-01)
A novel CC chemokine was identified in the thymus of mouse and human and was designated TECK (thymus-expressed chemokine). TECK has weak homology to other CC chemokines and maps to mouse chromosome 8. Besides the thymus, mRNA encoding TECK was
Siying Zhu et al.
PloS one, 9(6), e100167-e100167 (2014-06-18)
Natural killer T (NKT) cells share phenotypic and functional properties with both conventional natural killer cells and T cells. These cells might have an important role in the pathogenesis of ulcerative colitis (UC). The interaction of chemokine ligand 25 (CCL25)

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